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10.3109/0886022x.2014.986005 173 UngvariZ.SonntagW

FABPs, have high affinity for FAs, bile, and retinoids (213) and have been shown to play a role in transporting FAs between adipocytes and cancer cells in which pharmacological inhibition of FABP4 reduces TAG content in ovarian cells and aggressiveness

In a study by CHEN F et al., PNMC administration decreased spindle density and increased spindle length, thereby disturbing spindle stability, and the spindle pole position of the oocyte microtubule-severing enzyme Fignl1 was weakened in oocytes exposed to PNMC, which may have led to defects in its spindle apparatus [64]

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However, despite the good pharmacological properties shown by this molecule on several cancers, its use in the clinic is problematic because of its strong diuretic properties

doi: 10.4331/wjbc.v11.i3.99 164 PangM.GabelleA.Saha-ChaudhuriP.HuijbersW.GafsonA.MatthewsP