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Current Neuropharmacology, 18 (2), 108117

Treatment should be directed at the cause: moisturising the nail folds, avoiding repeated trauma from harsh manicures, checking for fungal infections when indicated, and correcting deficiencies when present

This is not unexpected, however, since a variety of neurotransmitters and hormones are able to modulate the electrical activity of GHRH neurons in the arcuate nucleus, and/or to modulate GHRH secretion at the median eminence 20

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COX-2 is normally inactive, but can be turned on during inflammation to produce pro-inflammatory prostaglandins