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This approach revealed two low signal clusters characterized by a high ribosomal gene signature and/or low UMI count in the sub-chronic smoke model dataset that were excluded from further analysis ( Supplementary Figure S7B )

This distinction is crucial because different regions of the respiratory system have varying sensitivities to harmful substances

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When asking "do cigarettes dehydrate you," the answer is yes, primarily through several mechanisms: Nicotine's diuretic effect increases urination frequency Smoking elevates heart rate and metabolism, accelerating water loss Chemicals in cigarettes can reduce saliva production, causing dry mouth Smoking damages mucous membranes, affecting moisture retention These effects combine to create a dehydrating impact that many smokers experience but may not recognize as dehydration